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Organic compounds that contain a carboxyl group bonded to an organic functional group; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from carboxylic acids.
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GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1 1 M 5 M for RSV RdRp and HCV RdRp respectively GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734)[1][2]
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Azido-PEG6-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
PEG-based PROTAC linker
Suitable for synthesizing PROTACs
Click chemistry reagent due to azide group
Enables CuAAc reactions
Participates in SPAAC reactions with DBCO or BCN groups
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Azido-PEG2-CH2COOH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It can also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
Functions as a click chemistry reagent
Contains an azide group
Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
Engages in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
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Lithium Citrate is a lithium-based compound widely utilized in biomedical research due to its ability to modulate mood stability and neuronal signaling Studies indicate that Lithium Citrate influences numerous biochemical pathways including enzyme inhibition and neurotransmitter regulation contributing to mood stabilization effects seen in bipolar disorder (BD) models Experimentally Lithium Citrate has shown capability in reducing self-injurious behaviors and addressing acute manic episodes in BD research models Additionally it facilitates the dissolution of uric acid crystals proposing potential relevance in gout-associated investigations Lithium Citrate also displays inhibitory properties towards prostatic acid phosphatase (PAP) a mechanism behind some observed side effects Currently detailed IC50 data for Lithium Citrate s enzyme inhibition effects remain limited in literature
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Sodium citrate (CAS 68-04-2) is a tricarboxylate anion derived from citric acid commonly supplied as a highly water-soluble white crystalline material Functioning as an alkalinizing agent sodium citrate acts by neutralizing hydrogen ions in physiological fluids thereby increasing systemic and urinary pH This buffering action is leveraged in studies of acid-base physiology metabolic acidosis and renal function In biomedical research sodium citrate is also frequently utilized as an anticoagulant in blood specimen preparation and as a component in cell culture systems requiring controlled pH environments
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MethADP triammonium (Adenosine 5'-(α,β-methylene)diphosphate triammonium) is a nucleotide analog used as a selective CD73 inhibitor for research into the ATP-adenosine pathway. Supplied as the triammonium salt, it is provided for laboratory research use in solid or solution form.
CD73 inhibitor for ATP-adenosine pathway studies.
High purity: 99.9%.
Molecular weight 476.32 g·mol⁻¹; chemical formula C11H26N8O9P2.
Appearance: off-white to light yellow solid.
Storage: solid at 4°C; in solvent -80°C up to 6 months, -20°C up to 1 month.
Available in small solid quantities and as a 10 mM solution.
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Azido-PEG2-CH2COOH is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. It also functions as a click chemistry reagent, featuring an Azide group that can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Can be used in the synthesis of PROTACs.
Functions as a click chemistry reagent.
Azide group enables copper-catalyzed azide-alkyne cycloaddition.
Can undergo strain-promoted alkyne-azide cycloaddition with DBCO or BCN groups.
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